If you're concerned only about scooping a huge win, then betting the maximum amount could be the way to do it. Lower staking spins will be eligible for the same stake multiplier as larger stakes, but the payout will be substantially less. But you need to bear in mind that this amount is only achievable if you're betting the maximum. The chance to win a big sum of money from a single spin is a great attraction.
A lot of slot games draw players in by advertising an enormous maximum payout.